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Breast cancer staging

What is a "stage" of breast cancer?

When it concerns cancer, the word "stage” refers to the extent of the disease. Staging breast cancer involves both the size of the tumor and whether or not it has spread to other parts of the body such as the lymph nodes. Staging is very important because it helps healthcare professionals determine the best treatment options to fight your cancer.

Stages of cancer start at 0 and go up to 4, but they are written in Roman numerals (I – IV). The number implies how much the cancer has spread. Generally, a lower number means the cancer has not spread, or has spread less. A higher number means the cancer has spread more.

The stages of breast cancer and what they mean

Stage 0

Stage 0 breast cancer.

The tumor has stayed in the part of the breast where it started. The two stage 0 breast cancers, ductal carcinoma in situ (DCIS, cancer in the cells that carry milk) and lobular carcinoma in situ (LCIS, cancer in the cells of the glands that make milk), are different and are treated differently

Treatment.
Doctors usually don’t recommend any immediate treatment for women with LCIS. Close follow-up, however, is essential. Treatment of DCIS varies, but may include surgery and radiation

The stages of breast cancer and what they mean

Stage I

Stage I breast cancer.

The tumor has spread into nearby parts of the breast, but not outside of the breast. The tumor is 2 centimeters or smaller

Treatment.
A local therapy is likely, usually meaning surgery followed by radiation. This surgery may be a mastectomy, in which case the whole breast is removed. The lymph nodes under the arm may be removed. If a tumor is caught early, surgery may be able to remove all of it. And a breast reconstruction may be done after a mastectomy, either soon after the surgery or later

The stages of breast cancer and what they mean

Stage II Stage II

Stage II breast cancer.

The tumor is between 2 – 5 centimeters, or it has spread outside the breast to the lymph nodes under the arm on the same side as the breast cancer

Treatment.
Surgery and radiation are the usual treatments. Radiation may be considered even after a mastectomy. Adjuvant therapy such as hormone therapy or chemotherapy may be recommended after surgery

The stages of breast cancer and what they mean

Stage III Stage III

Stage III breast cancer.

The tumor is larger than 5 centimeters, or has spread to areas around the breast, such as the skin of the breast and the collarbone

Treatment.
Again, doctors recommend surgery to remove part or all of the breast (lumpectomy or mastectomy). Surgery is usually followed by an adjuvant therapy and radiation therapy. Larger stage cancers may be treated with chemotherapy before surgery as well, to help shrink the tumor (this is called "neoadjuvant therapy")

The stages of breast cancer and what they mean

Stage IV

Stage IV breast cancer.

The tumor has spread beyond the breast and nearby areas, possibly to the base of the neck, lungs, liver, bones, or brain

Treatment.
Systemic therapy like chemotherapy is the main treatment. Radiation therapy and surgery may also be used to provide relief from certain symptoms

What system do doctors use when staging breast cancer?

The Staging System of the American Joint Committee on Cancer, also referred to as the TNM system, is most often used by doctors to describe a patient's cancer. The TNM system involves three scores that describe:

  • The tumor type
  • Whether or not lymph nodes are involved
  • How far the cancer has spread

Tumor, Node, and Metastasis (TNM) staging

Primary tumor (T)

T0 There is no evidence of a tumor
Tis: The tumor is “in situ,” meaning it has not spread to nearby tissues
T1 The tumor cannot be seen without using imaging techniques
T2-4 The higher numbers indicate the size and extent of the primary tumor

Nodes (N)

N0 The cancer has not spread to the lymph nodes
N1-4 The cancer has spread to the lymph nodes. The higher numbers indicate how many lymph nodes are affected and how far away the cancer has spread

Metastasis (M)

M0 No distant metastasis, meaning the cancer has not spread to other organs
M1 Distant metastasis, meaning the cancer has spread to other organs

People fighting breast cancer who are in otherwise good health can take part in clinical trials of other new potential treatments.

Staging is complex, so be sure to ask your doctors and nurses any questions you have about it.

Learn about breast cancer risk factors

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US.XON.10.04.010 Last Update: May 2010